To achieve higher ROI with Amazon PPC, sellers must refine their ad campaigns for maximum efficiency. Start by targeting the right keywords, using both broad and exact match types to capture a wider audience. Regularly optimize bids based on performance data and set clear goals for each campaign. Utilize Amazon's automatic and manual targeting options to fine-tune your approach. Negative keyword targeting helps avoid wasted spend. A/B testing ad creatives, adjusting budgets, and focusing on high-converting products also boost performance. With consistent optimization and data-driven decisions, sellers can maximize returns on their PPC investments and drive profitable growth.